作为疾病修饰剂的比利韦丁:一个综合的观点
1Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Università Cattolica Del Sacro Cuore, Largo F. Vito, 1, 00168, Rome, Italy.
Free radical biology & medicine
|July 17, 2023
概括
血红素副产品比利维丁 (BV) 在各种疾病的临床前研究中显示出抗氧化和治疗潜力. 缺乏临床数据,阻碍其转化为疾病修饰剂.
科学领域:
- 生物化学 生化学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- Biliverdin (BV) 是一种血红素氧化酶 (HO) 活动的副产物,通常通过 Biliverdin 减少酶 (BVR) 减少为 bilirubin (BR).
- 抑制BVR导致BV积累,导致绿色黄.
- 临床前研究表明,BV具有抗氧化特性,并调节信号通路.
研究的目的:
- 审查 biliverdin 的潜在治疗应用.
- 突出将临床前发现转化为临床实践的局限性.
- 倡导基础和临床研究人员之间加强合作.
主要方法:
- 关于 biliverdin 的影响的临床前研究的文献综述.
- 分析 biliverdin 针对的信号通路.
- 检查与 Biliverdin 积累相关的条件.
主要成果:
- 比利韦丁表现出直接的抗氧化作用,并影响像BVR,sGC和AhR这样的途径.
- 临床前数据表明,在缺血/再输液,炎症,GVHD,病毒感染和癌症方面可能有好处.
- 对外源性BV的疗效和人类的药理动力学缺乏临床数据.
结论:
- 比利韦丁作为治疗剂具有前景,特别是在与自由基相关的疾病中.
- 缺乏临床验证和药理动力学数据阻碍了BV的治疗发展.
- 增强的翻译研究对于确定 biliverdin 作为疾病修饰剂至关重要.
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