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对患双相情感障碍风险的个人进行预防性干预:系统性审查和元分析
Meng Fang1, Zili Fan1, Shanshan Liu1
1The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
早期干预有望减少情感症状,并为患双相情感障碍 (BD) 风险的人提供长期益处. 需要进一步的研究来证实这些发现.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 患双相情感障碍 (BD) 风险较高的人可能会从早期干预中受益.
- 情感症状和长期结果是风险人群的关键问题.
研究的目的:
- 系统地审查和元分析早期干预措施在减少情绪症状方面的有效性.
- 评估对患有双相情感障碍风险的个体进行干预的长期益处.
主要方法:
- 在PubMed,Embase和Web of Science数据库中的系统文献搜索.
- 包括10个受控和6个单臂研究.
- 随机效应的元分析,以计算主要结果的聚合平均差异估计.
主要成果:
- 与安慰剂相比,干预措施显著降低了临床总分数 (SMD = -0.96).
- 药物治疗显示出长期的纵向效应 (SMD = -0.42).
- 药物治疗和心理治疗都对抑郁症状有效;药物治疗在单臂试验中也对催眠症症状表现出有效性.
结论:
- 早期干预措施在患有BD风险的个体中显示出有效性.
- 心理治疗可能对抑郁症状和长期低迷症管理有好处.
- 药物治疗可能适用于严重的低躁狂症状和功能障碍,但需要更强大的试验.
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