对于局部复发乳腺癌的第二种保守治疗:GEC-ESTRO瘤结果和预后因素分析
Jean-Michel Hannoun-Levi1, Jocelyn Gal2, Csaba Polgar3
1Department of Radiation Oncology, Antoine Lacassagne Cancer Centre, University Cote d'Azur, Nice, France.
概括
第二种保守治疗 (第二次CT) 结合淋巴切除术和加速部分乳腺再照射 (APBrI) 为第二次ipsilateral乳腺瘤事件 (第二次IBTE) 提供了治疗选择. 新的TAM得分有效地预测了这些患者的瘤结果.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 手术瘤学手术瘤学
背景情况:
- 第二次ipsilateral乳腺瘤事件 (2次IBTE) 需要有效的治疗策略.
- 第二种保守治疗 (第二次CT),包括乳房切除和加速部分乳房再照射 (APBrI),是管理第二次IBTE的可行选择.
研究的目的:
- 分析第二次IBTE的第二次CT接受的患者的瘤预后因素.
- 评估一种新的预后得分 (TAM得分) 在预测第二次IBTE的结果中的有效性.
主要方法:
- 在7个欧洲中心使用GEC-ESTRO数据库对508名患者进行了回顾性分析.
- 患有第二次IBTE的患者接受了基于支臂治疗的APBrI的第二次CT.
- 患者使用Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) APBI风险组,分子分类和时间间隔 (TIS1S2) 进行分类,导致TAM得分的发展.
主要成果:
- 第二次局部复发的五年累计发病率为4%.
- 远程转移的五年累计发病率为7%,无病和总生存率分别为89%和91%.
- TAM评分是大多数瘤结局的独立预后因素 (P < .001). 晚期毒性≥3级发生在12.1%的患者中.
结论:
- 第二种保守治疗 (第二次CT) 结合淋巴切除术和APBrI,为第二次IBTE提供了出色的瘤结果.
- GEC-ESTRO TAM评分是指导第二IBTE患者治疗决策的宝贵预后工具.
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