Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Reticular Dermis01:15

Reticular Dermis

2.6K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
2.6K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

394
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
394

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Secondary metabolites isolated from <i>Agrimonia pilosa</i> Ledeb.

Natural product research·2020
Same author

Photoredox-Enabled Synthesis of β-Substituted Pyrroles from Pyrrolidines.

The Journal of organic chemistry·2020
Same author

VF-13, a chimeric peptide of VD-hemopressin(α) and neuropeptide VF, produces potent antinociception with reduced cannabinoid-related side effects.

Neuropharmacology·2020
Same author

Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha.

Thoracic cancer·2020
Same author

Two new Cu(II)-based coordination polymers: inhibitory activity on prostate cancer by reducing EGF-R expression and HIPPO signaling pathway activation.

Journal of biomaterials science. Polymer edition·2020
Same author

Thermosensitive heparin-poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury.

Journal of cellular and molecular medicine·2020

相关实验视频

Updated: Jul 23, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.3K

一种对炎症有反应的双层微针贴片,用于治疗复发性亚托皮炎.

Liwan Song1, Junjie Chi2, Zhenglin Li3

  • 1Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325025, China; School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, 325025, China.

International journal of pharmaceutics
|July 17, 2023
PubMed
概括

这项研究引入了一种对炎症反应敏捷的微针贴片,可提供维生素D3 (VD3) 用于亚托皮炎 (AD) 治疗. 该贴片有效地治疗AD症状,并通过释放VD3和氨酸作为对炎症的反应来预防复发.

关键词:
亚托邦性皮肤炎 (Atopic Dermatitis) 是一种不良的疾病.这是一个双层的双层.具有炎症反应的炎症反应.微针微针的使用方法预防复发 防止复发

更多相关视频

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

563
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K

相关实验视频

Last Updated: Jul 23, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.3K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

563
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K

科学领域:

  • 生物材料科学 生物材料科学
  • 皮肤病学 皮肤病学
  • 纳米技术 纳米技术

背景情况:

  • 亚托皮炎 (AD) 对有效治疗和预防复发提出了重大挑战.
  • 目前的治疗策略往往难以提供持续的缓解和治疗疾病复发.
  • 迫切需要创新的方法来有效管理AD.

研究的目的:

  • 开发一种对炎症有反应的双层微针 (IDMN) 贴片,用于在现场输送维生素D3 (VD3) 治疗复发性亚托皮性皮炎 (AD).
  • 调查IDMN贴片的治疗疗效和复发预防能力.
  • 探索VD3和氨酸 (HA) 在治疗AD中的协同效应.

主要方法:

  • 一个IDMN贴片的制造,其内层是装载VD3的凝甲烯基 (GelMA) 层,外层是氨酸 (HA) 层.
  • 利用基因金属蛋白酶 (MMP) 对GelMA的炎症反应降解来控制VD3的释放.
  • 评估IDMN贴片在AD携带小鼠模型中的性能,评估症状缓解和复发抑制.

主要成果:

  • IDMN贴片显示出高效的治疗效果,包括抑制红斑,化和化,以及减少表皮厚度和炎症.
  • 释放的VD3和溶解的HA之间的协同作用有助于观察到的"固化"性能.
  • 在初始治疗后留在皮肤中的微针尖残留物显示出抑制AD复发的"警告"能力.

结论:

  • 开发的IDMN贴片通过提供局部的,对炎症有反应的VD3输送,为亚托皮炎 (AD) 提供了一个有前途的治疗策略.
  • 贴片的双重作用,即缓解症状和预防复发,突出了其在治疗复发性皮肤疾病方面的潜力.
  • IDMN贴片代表了在治疗阿尔茨海默病和其他复发性炎症病症方面临床应用的创新候选者.