用于有效的抗微生物和抗氧化作用的含有芳香五环异环的奇托衍生物的制备
Jingmin Cui1, Yan Sun1, Linqing Wang2
1Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China; University of Chinese Academy of Sciences, Beijing 100049, China.
International journal of biological macromolecules
|July 17, 2023
概括
具有芳香异环的新奇桑衍生物显示出强大的抗真菌和抗菌活性. 这些化合物表现出强烈的抗氧化特性,并且无毒,使它们成为农业生物材料的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 农业科学 农业科学
背景情况:
- 奇托是一种天然聚合物,由于水溶性差,其应用有限.
- 开发新的奇托衍生物对于增强生物活动和材料特性至关重要.
- 芳香的五个组成的异环环具有功能化素的潜力.
研究的目的:
- 合成和表征9种新的基托衍生物,包括芳香的五个成员的异环环.
- 研究不同接种方法对这些衍生物的生物活性的影响.
- 评估这些衍生品在农业中作为抗真菌和抗菌生物材料的潜力.
主要方法:
- 合成9种基托桑衍生物与芳香的五个成员的异环.
- 使用福里埃变换红外 (FT-IR) 和核磁共振 (NMR) 光谱学进行结构性表征.
- 对抗氧化剂,抗真菌,抗菌和细胞毒性活动的评估.
主要成果:
- 奇托桑衍生物显示出对Fusarium graminearum,Fusarium oxysporum,Staphylococcus aureus和埃舍里希亚大肠杆菌的显著抑制作用.
- 几种衍生品对DPPH和超氧化激素表现出强烈的清除活性.
- 细胞毒性测试证实了一些衍生品对L929细胞的无毒性.
- 与原生奇多相比,合成的衍生品显示出更好的水溶性.
结论:
- 新型基托衍生物具有显著的抗微生物和抗氧化特性.
- 这些衍生品显示出作为有效和安全的生物材料用于农业应用的前景.
- 增强的水溶性和生物活性使它们优于未经修改的酸盐.
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