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Updated: Jul 31, 2026

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation
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A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

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通过新设计的循环金属化复合体抑制粉样β-β2聚合

Rahul Saini1, Govinda R Navale1, Sain Singh1

  • 1Department of Chemistry, Indian Institute of Technology, Roorkee 247667, India.

International journal of biological macromolecules
|July 17, 2023
PubMed
概括

新的复合体在预防粉样蛋白聚合方面表现有前途,粉样蛋白聚合是阿尔茨海默氏症等神经退行性疾病的关键因素. 这些化合物干扰蛋白质自我识别途径,减少有害纤维的形成.

关键词:
聚合和分子对接.Aβ ((142)) 类.帕拉迪乌姆复合体是一个复合体.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...