运动负荷,静止心率和最大心率之间的关联以及未来ST段升高心肌梗塞 (STEMI) 的风险
Edvin Helleryd1,2, Araz Rawshani3,2, Aidin Rawshani3,2
1Department of Molecular and Clinical Medicine, University of Gothenburg, Goteborg, Sweden edvin.helleryd@gu.se.
休息心率 (RHR) 是ST段升高心肌梗塞 (STEMI) 风险的关键指标. 高RHR (>90bpm) 几乎增加了三倍的风险发展STEMI,独立于运动能力.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 运动生理学 运动生理学
背景情况:
- 在全球范围内,ST段升高心肌梗塞 (STEMI) 仍然是导致死亡的主要原因.
- 确定STEMI风险的可靠预测因素对于有效的预防策略至关重要.
- 运动参数和心率在STEMI发展中的作用需要进一步阐明.
研究的目的:
- 研究休息心率 (RHR),运动工作量和最大心率与发展STEMI的风险之间的关联.
- 确定RHR是否是STEMI的独立预测因素.
- 量化与不同RHR水平相关的风险.
主要方法:
- 对接受了亚最大运动压力测试的英国生物库参与者的分析.
- 排除以前有STEMI病史的个人.
- 考克斯回归分析以评估运动耐受性,RHR和STEMI发病率之间的关系.
主要成果:
- 总共有66,949名参与者被分析,其中274人在7.7年内发展成STEMI.
- 休息心率 (RHR) 显示在调整多个临床因素后,与STEMI风险有显著的关联 (p=0.015).
- 在最高RHR四分位数 (>90bpm) 的参与者与最低四分位数相比,STEMI的风险增加了2.92倍.
结论:
- 休息心率 (RHR) 是未来ST段升高心肌梗塞 (STEMI) 的独立预测因素.
- 超过90次/分钟的RHR与STEMI风险增加近三倍有关.
- 在这个队列中,运动工作量和最大心率并不是STEMI的显著预测因素.
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