在先天性心脏病 (COaCHeD) 研究中的COVID-19
Sian Chivers1,2, Aoife Cleary2,3, Rachel Knowles4,5
1Department of Congenital Cardiology, Royal Brompton & Harefield NHS Foundation Trust, London, UK.
Open heart
|July 17, 2023
概括
对于患有先天性心脏病 (CHD) 的儿童来说,COVID-19的死亡风险很低. 然而,患有心血管疾病的成年患者面临死亡和住院的风险增加,特别是在晚年,并发症和肺动脉高血压方面.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19已导致全球显著的发病率和死亡率.
- 先天性心脏病 (CHD) 可能会增加对严重COVID-19结果的脆弱性.
- 了解心脏病患者不良结果的预测因素对于优化大流行期间的护理至关重要.
研究的目的:
- 确定COVID-19对患有心血管疾病的个体的影响.
- 确定与COVID-19感染后的CHD患者不良结果相关的风险因素.
主要方法:
- 一项多中心英国研究于2020年3月至2021年6月进行.
- 收集了关于心脏病诊断,临床表现和结局的数据.
- 多变量逻辑回归与多次归算被用于识别死亡和住院预测因素.
主要成果:
- 这项研究包括405例病例 (127例儿科病例,278例成人病例). 儿童死亡率为3.9%,老年儿童住院率较低.
- 成人死亡率为8.6% (19有并发症),住院率为26.6%.
- 增加的年龄和肺动脉高血压 (PAH) 预测了成年人的死亡. 年龄,并发症和遗传疾病预测了成年人住院的情况.
结论:
- 患有心血管疾病的儿童,即使是严重的病例,死于COVID-19的死亡和住院的风险也很低.
- 患有心血管疾病的成年人面临着随着年龄和PAH的增加而增加的死亡风险,以及随着年龄,并发病症和遗传疾病而增加的住院风险.
- 建议针对心血管疾病患者的COVID-19管理采用个性化的方法,考虑年龄和并发症.
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