对于严重烧伤患者的肠道谷氨胺补充剂:系统性审查和元分析
Han-Yang Yue1, Yu Wang2, Jun Zeng3
1Institute for Emergency and Disaster Medicine, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
概括
肠道谷氨酸可能不会改善严重烧伤患者的死亡率,但与更短的住院时间和减少伤口感染风险有关. 这次审查更新了关于谷氨胺有效性的先前发现.
科学领域:
- 医学研究 医学研究
- 临床营养学 临床营养学
- 燃烧管理 燃烧管理
背景情况:
- 2009年之前的研究表明,在严重烧伤患者中,谷氨酸可能会缩短住院时间 (LOS).
- 最近的研究表明,在过去十年中,谷氨胺在治疗严重烧伤的有效性可能会下降.
研究的目的:
- 进行系统性审查和元分析,以更新对严重烧伤患者中谷氨酸功效的理解.
- 评估肠道谷氨酸对死亡率,传染病和住院时间的影响.
主要方法:
- 在2022年12月之前发表的随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了多个数据库 (PubMed,科学网,科克兰图书馆,Embase,SinoMed,万芳,CNKI) 使用诸如"胺","肠道"和"烧伤"等术语.
- 使用修改的Jadad尺度和Cochrane协作工具评估偏差风险;使用审查经理5.4汇总数据.
主要成果:
- 分析了6个RCT,其中包括1398名患者.
- 在整体死亡率或传染病发病率方面没有发现显著差异.
- 肠道谷氨酸与较短的LOS (平均差异-8.97天) 和减少伤口感染发病率的趋势有关.
结论:
- 肠道输入谷氨胺可能不会改善严重烧伤患者的死亡率.
- 它与较短的LOS,较低的LOS/总烧伤表面积比率,以及潜在的减少伤口感染风险有关.
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