催产素:生理学,药理学和临床应用,用于劳动管理
Amy C Hermesch1, Annessa S Kernberg1, Vanessa R Layoun1
1Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR.
American journal of obstetrics and gynecology
|July 17, 2023
概括
高剂量的催产素和积极的分娩管理有效地缩短了分娩时间,并减少了膜炎. 没有增加对母亲或胎儿不良后果的风险证实了安全性,支持其在产科中的使用.
科学领域:
- 产科和妇科 产科和妇科
- 生殖内分泌学 生殖内分泌学
- 药理学 药理学是指药理学的学科.
背景情况:
- 催产素是女性生殖,分娩和哺乳的关键类激素,在下丘脑中产生,由后垂体释放.
- 在医学上使用时,催产素会刺激子宫收缩,帮助劳动诱导或增强.
- 之前的研究已经通过随机试验调查了催产素的疗效和安全性,比较了低剂量和高剂量疗法,通常是在积极的劳动管理策略中进行的.
研究的目的:
- 审查生理学,药理学,输液方案和催产素在分娩中的安全性.
- 评估不同的催产素剂量策略的有效性和安全性.
主要方法:
- 对比低剂量和高剂量催产素治疗方案的随机试验的综述.
- 分析涉及催产素的劳动策略的积极管理.
- 评估安全参数,包括胎儿心率,产后出血和新生儿结局.
主要成果:
- 高剂量的催产素和积极的分娩管理缩短了分娩时间,并减少了临床肌炎.
- 在高剂量方案中没有观察到胎儿或母亲不良结果的风险增加.
- 剖腹产分娩率在不同的催产素策略中保持相似.
结论:
- 催产素是产科中管理分娩的重要工具,高剂量疗法证明了有效性和安全性.
- 精确的施用和密切的监测是必要的,以减轻与催产素的潜在危害相关的风险,如果滥用.
- 本综述提供了对催产素生理学,药理学,施用方案以及产科实践中的相关风险的全面概述.
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