在囊性纤维化症中获得黄金葡萄球菌的种族差异
Meghan E McGarry1, Chiung-Yu Huang2, Ngoc P Ly1
1Division of Pediatric Pulmonology, Department of Pediatrics, University of California, 550 16th Ave, Box 0632, San Francisco, CA 94158, United States.
概括
患有囊性纤维化 (CF) 的西班牙裔个体患有金黄色葡萄球菌 (S. aureus) 的风险更高,包括对甲素敏感的金黄色葡萄球菌 (MSSA) 和对甲素耐药的金黄色葡萄球菌 (MRSA). 他们也在较年轻时获得这些感染,可能有助于增加CF发病率.
科学领域:
- 传染性疾病 传染性疾病
- 遗传学和基因组学 遗传学和基因组学
- 公共卫生 公共卫生
背景情况:
- 与非西班牙裔白人相比,患有囊性纤维化 (CF) 的西班牙裔个人患病率更高.
- 在西班牙裔CF患者中,发现Pseudomonas aeruginosa感染的风险增加.
- 这项研究调查了CF患者中黄金葡萄球菌 (S. aureus) 获取的种族差异.
研究的目的:
- 为了确定西班牙裔和非西班牙裔白种人之间是否有S. aureus获取的差异,CF.
- 根据种族,比较感染甲素敏感黄金菌 (MSSA) 和甲素耐药黄金菌 (MRSA) 的风险.
- 分析CF人口中不同族群中S. aureus感染的获得年龄.
主要方法:
- 一项纵向队列研究分析了CF基金会患者登记处0-25岁个体的数据.
- 在西班牙裔和非西班牙裔白色CF患者之间比较MSSA,MRSA和持久MRSA的获取.
- 利用卡普兰-梅尔曲线和考克斯回归模型,调整多个混变量.
主要成果:
- 西班牙裔CF患者患MSSA (19%更高) 和MRSA (13%更高) 的风险明显高于非西班牙裔白人患者.
- 收购MSSA的风险在经过调整以考虑混因素后仍然很大.
- 与非西班牙裔白人患者相比,西班牙裔CF患者在平均年龄较小时获得MSSA和MRSA.
结论:
- 25岁以下患有CF的西班牙裔个人面临MSSA和MRSA的风险较高.
- 在西班牙裔CF患者中,早些时候获得S. aureus可能会导致其增加的发病率.
- 在S. aureus获取的种族差异突出了针对CF护理的有针对性的干预措施的潜在领域.
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