在支气管切除症中使用吸入式抗生素治疗,副作用,以及耐受性测试的评估;来自BATTLE随机对照试验的分析
Lotte C Terpstra1, Daphne van der Geest1, Inez Bronsveld2
1Department of pulmonary medicine, Northwest Clinics Alkmaar, Alkmaar, The Netherlands.
在支气管切除症患者中对托布拉米吸入溶液 (TIS) 的初始耐受性测试显示没有立即出现不良呼吸系统事件. 然而,在早期TIS治疗期间仍建议持续监测呼吸道过敏反应.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 支气管切除症的恶化通常用托布拉米吸入溶液 (TIS) 治疗.
- 指导方针建议在医院进行TIS耐受性测试,因为TIS可能导致咳和支气管的副作用.
- 关于TIS相关的呼吸系统不良事件的现有数据不一致.
研究的目的:
- 评估TIS在支气管切除症患者的初始耐受性测试的附加值.
- 在TIS治疗期间观察吸入治疗相关的支气管过敏反应的发展.
主要方法:
- 来自BATTLE研究 (NCT02657473) 的57名患者的分析.
- 患者接受TIS或安慰剂每天一次 (OD) 一年.
- 在第一剂之前和后进行了螺旋计和支气管扩展剂的耐受性测试;不良事件被监测.
主要成果:
- 所有57名患者都通过了初始耐受性测试,没有螺旋计变化或局部不耐受性.
- 五名接受TIS治疗的患者 (17.8%) 由于呼吸道过敏反应而退出治疗,而一个安慰剂患者 (3.5%).
- 没有发现其他与TIS相关的临床显著不良事件.
结论:
- 吸入药物,包括TIS,在支气管切除症患者中通常耐受良好.
- 对TIS的初始耐受性测试似乎在预测气道过敏反应方面没有额外的价值.
- 建议在TIS治疗的最初几周密切监测副作用.
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