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在2型糖尿病人群中恢复PITPNA可以逆转胰腺β细胞功能障碍

Yu-Te Yeh1,2, Chandan Sona1,2, Xin Yan3,4

  • 1Johns Hopkins University, All Children's Hospital, St. Petersburg, FL, 33701, USA.

Nature communications
|July 17, 2023
PubMed
概括

酸丁氨基转移蛋白α (PITPNA) 的缺陷会损害2型糖尿病中的胰岛素颗粒成熟和β细胞功能. 在人体小岛中恢复PITPNA可以扭转这些缺陷,突出其治疗潜力.

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