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阿克尔曼西亚尼菲拉抑制了由Fusobacterium nucleatum引起的牙周炎

Bingqing Song^1,2, Wenpan Xian^1,2, Yan Sun^1,2

¹State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, 610041, Chengdu, China.

NPJ biofilms and microbiomes

|July 17, 2023

概括

发现一种益生菌Akermansia muciniphila可以抑制Fusobacterium nucleatum,这是牙周炎的关键原因. 这一发现为治疗牙周炎和预防牙脱落提供了潜在的新策略.

科学领域:

微生物学微生物学
口腔健康口腔健康
免疫学免疫学免疫学

背景情况:

牙周炎是成年人牙损失的主要原因,与全身性疾病有关.
斑块生物膜,特别是Fusobacterium nucleatum,是牙周炎的主要原因.
目前的治疗方法,如缩放和根平整,是繁重的,抗生素有耐药性的风险.

研究的目的:

调查Akkermansia muciniphila (A. muciniphila) 作为一种益生菌的潜力,以抑制F.核和缓解牙周炎.
探索 A. muciniphila 影响 F. nucleatum 毒性和宿主炎症反应的机制.

主要方法:

细菌共同培养实验评估F.核病毒性基因表达.
用F. nucleatum和A. muciniphila治疗牙上皮细胞 (GEC),然后进行转录组测序和ELISA.
使用BALB/c小鼠进行动物实验,以评估A. muciniphila在牙周炎模型中的疗效.

主要成果:

A. muciniphila显著抑制了F. nucleatum病毒性基因的表达.
通过调节TLR/MyD88/NF-κB通路,A. muciniphila抑制了GEC中的F.核诱导的炎症.
在小鼠中,A. muciniphila治疗减少了F. nucleatum诱导的牙周炎的严重程度.

结论:

阿克尔曼西亚·穆西尼菲拉 (Akkermansia muciniphila) 显示出对Fusobacterium nucleatum的抑制作用.
A. muciniphila通过减少毒性因子表达和抑制炎症通路来减轻牙周炎.
这种益生菌有望成为预防和治疗牙周炎的新型治疗剂.

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