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工程瘤血管泄漏与金纳米颗粒的工程

Magdiel Inggrid Setyawati^1,2, Qin Wang³, Nengyi Ni⁴

¹National University of Singapore, Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, Singapore, 117585, Singapore. misetyawati@ntu.edu.sg.

Nature communications

|July 17, 2023

概括

研究人员开发出金纳米颗粒,使瘤血管泄漏,改善癌症药物输送,并导致动物模型中瘤完全回归. 这种方法提高了治疗瘤的机会.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗方法癌症治疗方法

背景情况:

癌症治疗药物的有效输送到瘤是由于血管透性不足而受到阻碍的.
瘤血管通常缺乏必要的泄漏性,使药物能够有效地透.

研究的目的:

通过使用纳米颗粒来改进瘤中增强的血管泄漏,以改善药物输送.
评估纳米粒子诱导的血管泄漏在促进治疗透和癌症回归方面的有效性.

主要方法:

开发用于诱导内皮泄漏 (NanoEL) 的金纳米颗粒.
在实体研究中,使用实时内存成像来观察纳米粒子对瘤血管系统的影响.
在NanoEL预治疗后,对原发性瘤和微转移的动物模型进行治疗疗效的评估.

主要成果:

NanoEL金纳米颗粒通过影响附着结,而无细胞毒性,诱导了内皮泄漏.
内腔成像证实NanoEL颗粒增加了瘤血管的透性和间隙空间的透.
使用纳米EL颗粒进行预处理导致原发性瘤和微转移的完全回归.

结论:

工程瘤血管泄漏是一种新的策略,以提高抗癌治疗的可访问性.
在癌症治疗中,NanoEL纳米颗粒提供了一种有希望的方法来克服药物输送障碍.
这种方法代表了范式的转变,专注于改善药物输送,而不是仅仅增加药物的效力.

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