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Updated: Jul 23, 2025

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酸盐激酶M2的代谢功能调节了活性氧物种的产生和中性粒细胞杀死微生物的功能

Juliana Escher Toller-Kawahisa1,2, Carlos Hiroji Hiroki3,4, Camila Meirelles de Souza Silva3,4

  • 1Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. jutoller@hotmail.com.

Nature communications
|July 17, 2023
PubMed
概括

酸盐激酶M2 (PKM2) 调节中性粒细胞的活性氧物种 (ROS) 生产和杀死细菌. 缺少PKM2会通过改变糖解,特别是二氧酸 (DHAP) 和二甲基甘油 (DAG) 合成来损害微生物的防御能力.

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