可打开的人造肠道装置与透式过器集成,用于评估药物通过细胞透的情况
Satoshi Konishi1,2,3,4, Shingo Ishibashi5, Shiho Shimizu5
1Department of Mechanical Engineering, College of Science and Engineering, Ritsumeikan University, Kusatsu, 525-8577, Japan. konishi@se.ritsumei.ac.jp.
Scientific reports
|July 17, 2023
概括
这项研究改进了用于药物查的芯片上的人造肠道器官. 改进的设备可以使用培养细胞分析药物吸收和透.
科学领域:
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 芯片上的器官是体外生物评估的宝贵工具.
- 之前的人工肠道模型促进了药物吸收查.
- 需要进一步开发来评估药物透率.
研究的目的:
- 为了改进一个人造肠道器官芯片系统.
- 为了分析药物的吸收和透.
- 推进体外药物查技术.
主要方法:
- 在现有的人工肌肉执行器驱动的肠道装置中集成透器.
- 使用 perfusion 测试评估过器的透性.
- 在设备上培养了MDCK-II细胞,并评估了细胞完整性和电特性.
主要成果:
- 成功地将波器集成到芯片上的器官设计中.
- 证明了该设备在评估药物透和吸收的同时评估药物透的能力.
- 在修改后的装置上确认了细胞活力和功能.
结论:
- 改进的人工肠道器官芯片系统增强了药物动力学分析.
- 该装置可方便进行全面的体外药物处置研究.
- 这项技术有望促进药物查和开发.
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