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相关概念视频

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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相关实验视频

Updated: Jul 17, 2026

A Murine Model of Subarachnoid Hemorrhage
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在急性腹腔内血瘤中脑输液的变化.

J Winkler1, G S Piedade2,3, C Rubbert4

  • 1Department of Neurosurgery, Heinrich-Heine-University, Düsseldorf, Germany.

Acta neurochirurgica
|July 17, 2023
PubMed
概括

急性亚皮血瘤 (aSDH) 显著影响大脑输液,特别是在受影响半球中提高最大时间 (Tmax). 在创伤性脑损伤患者中的这一发现可能会影响手术决策.

关键词:
急性皮下血液瘤急性皮下血液瘤通过CT perfusion进行CT perfusion,使得人体内产生更多的光线.大脑输液,大脑输液.创伤性脑损伤是一种创伤性脑损伤.

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科学领域:

  • 神经外科 神经外科
  • 放射学 放射学是一门学科.
  • 创伤护理 创伤护理

背景情况:

  • 急性亚皮血瘤 (aSDH) 是一种严重的创伤性脑损伤并发症,死亡率高.
  • 在SDH中,快速的体积变化和质量效应会损害大脑输液.
  • 早期检测和量化 perfusion 变化对于患者的结果至关重要.

研究的目的:

  • 用CT输液成像来量化急性腹腔内血瘤患者的脑输液变化.
  • 调查aSDH对受影响大脑区域的血液动力学参数的影响.
  • 为了将输液变化与临床数据相关联,并为治疗策略提供信息.

主要方法:

  • 54名创伤性aSDH患者的回顾性分析.
  • 评估CT输液成像 (CTP) 参数,包括Tmax,脑血流 (CBF),脑血体积 (CBV) 和平均传输时间 (MTT).
  • 对受影响和未受影响半球皮质输液的分析,包括特定区域,如血液瘤 (ABH) 下面的区域.

主要成果:

  • 与未受影响区域相比,在整个受影响半球 (4.0s vs 3.3s) 和血液瘤 (ABH) 下面的区域 (3.8s vs 3.1s) 观察到Tmax显著升高.
  • 在受影响地区和不受影响地区之间,CBF,CBV或MTT没有发现显著差异.
  • 特别注意的是,Tmax的升高是在aSDH底层的皮质区域.

结论:

  • 在急性腹腔内血瘤下方的皮质区域的Tmax显著升高表明大脑输液发生改变.
  • 这些输液变化,特别是Tmax升高,需要进一步研究其病理生理基础.
  • 了解这些 perfusion 动态对于指导 aSDH 患者立即手术决策和随后的管理至关重要.