全球多民族人群中心血管疾病的身体组成和风险因素
Jennifer L Carter1, Noraidatulakma Abdullah2, Fiona Bragg3,4
1Clinical Trial Service Unit and Epidemiological Studies, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. jennifer.carter@ndph.ox.ac.uk.
身体组成和心血管风险因素在各族群之间存在显著差异,包括中国人,马来人,印度人和白人. 了解这些变异对于全球解决与肥胖有关的疾病至关重要.
科学领域:
- 心血管健康 心血管健康
- 人类测量学 人类测量学.
- 人口健康 人口健康
背景情况:
- 缺乏对不同种族人体构成和心血管风险因素的大规模比较研究.
- 了解人体构成的种族差异对于有针对性的健康干预至关重要.
研究的目的:
- 为了比较身体组成指标和心血管风险因素之间的关联,跨越多民族人口.
- 为了研究人体测量和人体构成如何与不同种族群体的缩血压,胆固醇,甘油三和HbA1c有关.
主要方法:
- 利用了马来西亚队列 (马来人,印度人,中国人) 和英国生物银行 (白人成年人) 的数据.
- 采用性别特定的线性回归模型来分析身体质量指数 (BMI),腰围 (WC),脂肪质量,尾肌肉质量和心血管风险因素之间的关联.
- 包括人体测量和人体构成测量,以及缩血压 (SBP),低密度脂蛋白胆固醇 (LDL-C),甘油三和HbA1c.
主要成果:
- 与马来人和印度参与者相比,中国成年人的BMI和脂肪质量较低;白人参与者更高,尾肌肉质量更大.
- 体重指数/脂肪量和SBP/HbA1c之间的积极关联在中国人和马来人中最强,在白人中较弱.
- 根据种族,WC与风险因素之间的关联有很大差异,其中三甘油和HbA1c的关系有显著差异.
结论:
- 跨种族群体之间存在着不同的脂肪,身体成分和心血管风险因素的不同模式.
- 进一步研究将身体成分与心血管风险联系在一起的机制至关重要.
- 解决全球肥胖相关疾病的负担需要一个细微的,种族敏感的方法来理解身体组成.
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