症状持续时间与每次口腔内镜肌肉切除 (POEM) 失败无关
Christina S Boutros1,2, Saher-Zahara Khan3,4, Jamie Benson3,4
1Department of Surgery, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Lakeside 7, Cleveland, OH, 44106, USA. Christina.Boutros@UHhospitals.org.
Surgical endoscopy
|July 17, 2023
概括
长期存在的阿喀拉西亚症状不会影响每口腔内镜肌切除术 (POEM) 的成功. 这项研究发现,症状持续时间没有增加POEM失败率,为患者的资格提供了希望.
科学领域:
- 胃肠病学 胃肠病学
- 手术创新 在外科创新.
- 食道运动障碍 食道运动障碍
背景情况:
- 通过口腔内镜肌切除术 (POEM) 是一种用于治疗阿喀拉西亚的新型治疗方法.
- 在长期的阿喀拉西亚中,POEM的有效性仍然不清楚.
- 假设:较长的症状持续时间与较差的POEM结果相关.
研究的目的:
- 为了评估阿喀拉西亚症状持续时间对POEM成功的影响.
- 为了确定延长症状持续时间是否会影响POEM失败率.
- 为了为有关POEM资格的临床决策提供信息.
主要方法:
- 对132名接受POEM (2012-2022) 的阿喀拉西亚患者的回顾性分析.
- 患者根据症状持续时间 (<1, 1-3, 4-10, >10年) 分为分层队列.
- 通过重新干预,复发或高Eckart分数定义的POEM故障;使用多变量后勤回归.
主要成果:
- 群体之间的人口统计或并发症没有显著差异.
- 症状>10年的患者有更多的先前干预 (60%vs30%).
- 症状复发,POEM后症状和人体测量结果在所有持续时间队列中都相似.
结论:
- 长时间的阿喀拉西亚症状持续时间与增加的POEM失败无关.
- 无论症状持续时间如何,POEM仍然是一个可行的选择.
- 临床医生不应该仅仅根据症状持续时间将患者排除在POEM之外.
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