较差的衰老轨迹与较高的血清合成能力有关
Teodora Z Markova1, Claire J Ciampa2, Jourdan H Parent2
1Brandeis University, Waltham, MA, 02453, USA. teodoramarkova@brandeis.edu.
Molecular psychiatry
|July 17, 2023
概括
年龄较大的成年人表现出更高的大脑血清合成能力,这与大脑变化和抑郁症有关. 这种PET成像标记可能表明与阿尔茨海默病和情绪障碍相关的衰老轨迹.
科学领域:
- 神经科学是一个神经科学.
- 放射化学 放射化学是指辐射化学.
- 老年学是一门学科.
背景情况:
- 背脊拉菲核 (DRN) 对大脑的血清素至关重要,也是阿尔茨海默病 (AD) 的早期目标.
- 衰老会影响血清素系统,并与神经退行性变化和情绪障碍有关.
研究的目的:
- 测量DRN中使用[18F]Fluoro-m-tyrosine ([18F]FMT) PET在健康成年人一生中测量血清合成能力.
- 调查DRN血清素合成能力与与衰老相关的大脑结构变化,抑郁症症状和AD病理学之间的关系.
主要方法:
- 111名健康的成年人 (18-85岁) 接受了[18F]FMT PET,以量化DRN血清合成能力 (Ki).
- 研究了DRN [18F]FMT Ki和纵向MRI (皮层厚度),抑郁症得分以及横截面tau ([18F]Flortaucipir) 和粉样β ([11C]PiB) PET之间的相关性.
- 探索性分析考虑了性别差异.
主要成果:
- 与年轻人相比,在老年人中,DRN中的血清激素合成能力较高.
- 较高的DRN [18F]FMT Ki与较大的叶皮层缩和纵向抑郁症状增加相关,特别是在老年人中.
- 没有发现DRN血清素合成能力和AD tau或粉样β病理之间的直接关联.
- 具有最高血清激素合成能力的老年成年女性显示了内皮层tau与抑郁症之间最强的联系.
结论:
- 通过[18F]FMT PET测量DRN血清合成能力的提高,可能作为加速大脑衰老的生物标志物.
- 这一发现突显了血清激素系统变化,大脑结构变化和衰老中的情感福祉之间的相互作用.
- 血清素系统的PET成像为了解与AD和情绪障碍相关的衰老轨迹提供了一个有希望的途径.
更多相关视频
05:59Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
2.4K
10:19Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
14.3K
相关概念视频
01:26Aging
89
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
89
01:28Human Genetics
616
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
616
01:27Depressive Disorders: Etiology
140
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
140
01:29Psychological and Sociocultural Causes of Schizophrenia
142
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
142
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K