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Updated: Jul 23, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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对一种类型V-M CRISPR-Cas效应酶的机制和进化见解

Satoshi N Omura1, Ryoya Nakagawa1, Christian Südfeld2

  • 1Department of Biological Sciences, Graduate School of Science, the University of Tokyo, Tokyo, Japan.

Nature structural & molecular biology
|July 17, 2023
PubMed
概括

Cas12m2 CRISPR-Cas效应器使用强大的DNA结合用于细菌免疫,而不是DNA裂变. 结构研究揭示了其独特的RNA引导基因组失活和适应性免疫机制.

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