与自身免疫性缩性胃炎相关的高胃血症中的素水平
S Censi1, S Carducci1, G Zoppini2
1Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy.
Journal of endocrinological investigation
|July 17, 2023
概括
在患有自身免疫性缩性胃炎 (AAG) 的患者中,高素水平不会导致素 (Ct) 水平升高. 需要进一步的诊断评估,以排除高Ct和AAG的患者中髓性甲状腺癌 (MTC) 的可能性.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 素 (Ct) 是C细胞疾病的敏感标记物,如甲状腺髓癌 (MTC).
- Ct的特异性有限,需要对可能影响Ct水平的其他条件进行调查.
- 自身免疫性缩性胃炎 (AAG) 和慢性高胃血是潜在的混因素.
研究的目的:
- 为了调查AAG和慢性胃高血症,有或没有自身免疫性甲状腺炎 (AT),是否与Ct水平升高有关.
- 确定患有AAG和/或AT的患者的胃素水平和Ct水平之间的关系.
主要方法:
- 一项多中心研究纳入了三组患者:AAG (n=13),AAG与AT (n=92) 和AT没有AAG (n=37).
- 在所有患者群体中测量了卡尔西托尼和胃素水平.
- 进行了统计分析,以评估群体之间的相关性和差异.
主要成果:
- 在这三个组中,中位Ct水平没有显著差异.
- 所有组中的大多数患者都有不可检测或低Ct水平 (≤10 ng/L).
- 只有三名患有高Ct和高胃素水平的患者被诊断为MTC; Ct和胃素水平之间没有发现相关性.
结论:
- 患有AAG的患者胃素水平升高并不能解释高酸血症.
- 在AT的存在不会改变胃素和CT水平之间的关系.
- 在呈现高Ct水平和AAG的患者中,完成MTC的诊断工作至关重要.
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