哥伦比亚的自体主导多囊性病
Jessica T Camargo1, Camilo A González2, Lina Herrera3
1Fundación Universitaria Sanitas, Bogotá, D.C, Colombia.
BMC nephrology
|July 17, 2023
概括
哥伦比亚的自体主导多囊性病 (ADPKD) 患病率为每10万人中9.81. 在Valle del Cauca和Cali发现的比例更高,这表明遗传研究的潜在领域.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 自体主导多囊性病 (ADPKD) 是导致需要透析的慢性病 (CKD) 的主要遗传原因.
- 了解ADPKD的地理分布对于早期诊断,疾病管理和遗传咨询至关重要.
研究的目的:
- 确定哥伦比亚接受透析或移植的ADPKD患者的患病率,地理分布和种族人口统计.
- 在2015年至2019年期间,确定哥伦比亚境内ADPKD的地理集群.
主要方法:
- 一项采用哥伦比亚慢性病国家注册局 (NRCKD) 从2015年7月至2019年6月的数据进行的横截面研究.
- 包括哥伦比亚患有慢性病的个人,有或没有置换疗法 (RRT),特别是由于ADPKD.
- 根据州和城市分层估计的原始和调整的流行率.
主要成果:
- 总共分析了3339名ADPKD患者;每10万人口中月经患病率为9.81.
- 在Valle del Cauca (6.55/100,000) 和Cali (9.38/100,000) 发现了最高的调整流行率.
- 46.07%的患者开始定期透析,平均年龄为52.58岁; 52.78%是女性.
结论:
- 哥伦比亚的ADPKD患病率似乎低于欧洲和美国.
- 患病率较高的特定州,例如Valle del Cauca,需要进一步调查遗传患病率研究.
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