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Yuantao Li¹, Jingjing Guo¹, Haixia Zhang²

¹Department of Gynecology and Obstetrics, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, People's Republic of China.

Parasites & vectors

|July 17, 2023

概括

毒素菌感染降低了LILRB4表达在状骨髓衍生抑制细胞 (dMDSCs) 上的调节,损害了它们的功能. 这种功能障碍由SHP-2/STAT6通路介导,可能导致不良妊娠结果.

科学领域:

免疫学免疫学免疫学
生殖生物学生殖生物学
传染性疾病传染性疾病

背景情况:

毒素菌感染对怀孕构成风险,包括流产和胎儿形.
脱落性骨髓衍生抑制细胞 (dMDSCs) 对于通过免疫抑制维持正常怀孕至关重要.
白细胞免疫球蛋白样受体B4 (LILRB4) 在dMDSCs上高度表达,但其在T. gondii感染中的作用尚不清楚.

研究的目的:

调查T. gondii感染对dMDSC中的LILRB4表达的影响.
通过改变LILRB4表达来确定T. gondii感染是否诱导dMDSC功能障碍.

主要方法:

实验中使用了感染T. gondii的LILRB4缺乏孕妇小鼠.
试验室研究涉及感染人类dMDSCs的抗LILRB4抗体治疗.
分析的重点是调节dMDSC功能的分子通路.

主要成果:

淋巴菌感染减少了STAT3酸化,导致dMDSCs上的LILRB4表达减少.
减少LILRB4表达减少了dMDSC中的关键功能 (阿基纳-1,IL-10) 和信号 (p-SHP2,p-STAT6) 分子.
确定了SHP-2/STAT6通路是将LILRB4下调与降低的Arg-1和IL-10联系起来的机制.

结论:

淋巴菌感染对dMDSCs降低LILRB4的调节,通过SHP-2/STAT6通路引起它们的功能障碍.
这种dMDSC功能障碍是由LILRB4减少所驱动的,可能会导致毒素菌的不良妊娠结果.

关键词:

决定性的MDSCs.功能障碍功能障碍是指一种功能障碍.胎儿胎儿胎儿的意思这就是LILRB4的原因.母亲的耐受能力.这种毒性淋巴细胞 (Toxoplasma gondii) 是

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