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在BRAF和RAS等乳腺状甲状腺癌的不同分子表型的进展
Jinsun Lim1, Han Sai Lee2,3, Jiyun Park1,4
1Department of Medicine, CHA University School of Medicine, Seongnam, Korea.
Endocrinology and metabolism (Seoul, Korea)
|July 18, 2023
概括
乳头甲状腺癌 (PTC) 亚型BRAF类 (BL) 和RAS类 (RL) 呈现出不同的进展机制. BL-PTC进展涉及细胞外基质和纤维细胞,而RL-PTC涉及免疫反应的改变.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 乳头甲状腺癌 (PTC) 有两种亚型:类似BRAF的 (BL) 和类似RAS的 (RL).
- 这些亚型相对于临床病理因素的分子特征尚未完全理解.
- 研究这些差异可以揭示不同的进展机制.
研究的目的:
- 研究BL-PTC和RL-PTC中的基因特征和瘤微环境.
- 为了确定在每个亚型中推动进展的独特分子机制.
- 为了将分子发现与临床病理学因素相关联.
主要方法:
- 来自503名PTC患者的RNA测序数据的分析 (癌症基因组图谱).
- 不同基因表达 (DEG),基因本体学和通路丰富分析.
- 使用EcoTyper和CIBERSORTx.x.进行瘤微环境解密.
主要成果:
- BL-PTC和RL-PTC显示不常见的DEG重叠,表明不同的进展途径.
- 细胞外基因矩阵基因在积极的BL-PTC中被上调 (老年,甲状腺外延伸,转移,高级TNM/MACIS阶段).
- 与癌症相关的纤维细胞富含BL-PTC;免疫/免疫球蛋白基因下调与RL-PTC中的攻击性相关.
结论:
- 癌症进展的分子表型在BL-PTC和RL-PTC之间有显著差异.
- 细胞外基质和与癌症相关的纤维细胞在BL-PTC进展中至关重要,在晚期病例中普遍存在.
- 不同的微环境和遗传因素驱动每个PTC亚型的进展.
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