在胃肠道症状和死亡率上,COVID-19阿尔法变异B.1.1.7和原始病毒之间的区别:是否存在负相关性?
Yaron Niv1, Michael Kuniavsky2, Olga Bronshtein2
1Israeli National Program for Quality Indicators (INPQ), Ministry of Health, Jerusalem, Israel, Ariel University, Faculty of Medicine, Ariel, Israel.
The Israel Medical Association journal : IMAJ
|July 18, 2023
概括
在早期的COVID-19浪潮中,胃肠道症状更为常见. 然而,后来的波浪,包括阿尔法变异,显示出更高的死亡率和更少的胃肠道症状.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 胃肠道 (GI) 症状在COVID-19患者中很常见,影响高达50%.
- 胃和肠上皮细胞表达病毒入口受体ACE2和TMPRSS2,使它们易受SARS-CoV-2感染.
- 本研究研究了以色列在不同COVID-19波及变种期间的胃肠道症状和死亡率.
研究的目的:
- 在以色列COVID-19大流行期间的两个不同时期调查胃肠道症状的流行情况.
- 为了将胃肠道症状的存在与这些时期的患者死亡率相关联.
主要方法:
- 这是一项多中心的回顾性队列研究,涉及4688名住院患者.
- 患者从两个时期中选择:第1期 (第一波和第二波,原始病毒) 和第2期 (第三波,阿尔法变异).
- 这项研究是在疫苗普及之前进行的.
主要成果:
- 胃肠道症状 (腹,吐,腹痛,味觉/嗅觉丧失) 在第一期显著增加.
- 在第二期,三十天死亡率为25.20%,而在第一期为13.68%.
- 在第二期,住院死亡率为21.17%,而在第一期为12.87% (P < 0.001).
结论:
- 在第二期 (阿尔法变异波) 中,死亡率显著上升.
- 在胃肠道症状和死亡率之间观察到负相关性.
- 30天和住院死亡率分别是第2期阿尔法变异激增期间的1.84倍和1.64倍.
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