相关实验视频
Updated: Jul 23, 2025

16:15
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
20.7K
移植后的复发性膜增殖性淋巴结膜炎:风险因素和对移植存活的影响
Lais Ceccatto de Paula1, Marilda Mazzali1, Marcos Vinicius de Sousa1
1Renal Transplant Research Laboratory, Renal Transplant Unit, Division of Nephrology, Department of Internal Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Annals of transplantation
|July 18, 2023
概括
移植脏后的膜增殖性血球炎 (MPGN) 复发发生在25%的患者中,通常在接受活体捐赠脏的患者中. 复发呈现出瘤综合征和C3消耗,但5年移植存活率仍然很高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 淋巴细胞疾病 淋巴细胞疾病
背景情况:
- 膜增殖性淋巴结膜炎 (MPGN) 是末期病 (ESRD) 的罕见原因之一.
- 移植后的MPGN复发是一个重大问题,报告的发病率在5年和15年之间为11.8%至18.9%.
研究的目的:
- 评估移植后与MPGN复发相关的风险因素.
- 评估MPGN复发对移植存活和功能的影响.
主要方法:
- 移植患者的回顾性队列研究,诊断出MPGN在本土脏中.
- 对移植后前5年的医疗记录进行分析.
- 主要终点:移植功能和存活率;次要终点:复发风险因素和临床特征.
主要成果:
- 在28名被纳入患者中,MPGN复发在25%的患者中被观察到.
- 复发病例主要是男性 (85.7%),并从活体捐赠者 (57.1%) 获得脏.
- 在复发病例中,瘤综合征,血液和C3消耗 (71.4%) 是常见的;移植功能在各组之间是相似的.
结论:
- 该研究确定了25%的MPGN复发率,活着的捐赠者接受者中占有显著比例.
- 瘤综合征和C3消耗是复发的关键指标.
- 尽管发生了复发,但与其他研究相比,这个队列中的5年移植存活率是有利的.
相关概念视频
Kidney Transplant II: Surgical Procedure
36
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
36
Kidney Transplant III: Nursing Management
39
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
39
Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
Acute Kidney Injury III: Clinical Manifestations
37
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
37
Acute Kidney Injury II: Pathophysiology
34
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
34
Tissue Transplantation
408
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
408

