石榴汁对血压的影响:系统性审查和元分析
Fatemeh Ghaemi1, Maryam Emadzadeh2, Stephen L Atkin3
1Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytotherapy research : PTR
|July 18, 2023
概括
摄入石榴汁 (PJ) 显著降低了静缩和静缩血压,特别是在每天300毫升以下的剂量和持续时间长达两个月的情况下. 血压降低PJ的作用是剂量依赖的.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 临床营养学 临床营养学
背景情况:
- 富含多的水果对心血管健康至关重要,但石榴汁 (PJ) 对血压的具体影响仍然不完全理解.
- 现有研究对PJ在调节血压水平中的有效性提出了相互矛盾的发现.
研究的目的:
- 系统地评估石榴汁对血压的影响.
- 综合PJ和血压临床试验的定量数据.
主要方法:
- 在PubMed,Scopus,ISI科学网和Cochrane图书馆进行了全面的文献搜索.
- 包括仅使用石榴汁的人类研究,仅限于英语出版物.
- 对14项临床试验 (n=573) 的元分析,使用随机效应模型和通用逆方差方法.
主要成果:
- 分析显示,随着PJ (MD: -5.02 mmHg) 系统血压 (SBP) 的显著降低.
- 摄入量≤300毫升/天PJ显著降低了SBP (MD: -6.11 mmHg).
- 在≤2个月的PJ摄入量显著降低了SBP和透气血压 (DBP);在2个月后,益处减少了.
结论:
- 石榴汁在降低静缩和静缩血压方面表现出显著的剂量依赖作用.
- 对于降低血压的最佳益处是在每日摄入≤300毫升,持续时间长达两个月时观察到的.
- 进一步的研究可能是有必要的,以探索长期影响和最佳的消费模式,以获得持续的心血管益处.
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