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胸部SMARCA4缺陷不分化的瘤的一个子集表达GATA3

Daniel Martinez Coconubo^1,2, Sintawat Wangsiricharoen³, Jason R Pettus^1,2

¹Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, USA.

International journal of surgical pathology

|July 18, 2023

概括

胸部SMARCA4缺乏的未分化瘤 (SMARCA4-UT) 是一种侵略性瘤. 在44%的病例中观察到GATA3表达,这给诊断带来了挑战,并影响了治疗决策.

科学领域:

在瘤学瘤学.
病理学病理学病理学
分子生物学分子生物学

背景情况:

胸部SMARCA4缺陷不分化的瘤 (SMARCA4-UT) 是一种罕见的,具有攻击性的瘤.
SMARCA4-UTs是由不分化的形态和SMARCA4基因突变来定义的,导致BRG1表达的丧失.
在SMARCA4-UTs.中注意到其他标记物的变量表达.

研究的目的:

在一系列SMARCA4-UTs中描述GATA3免疫反活性现象.
调查这些瘤中GATA3表达的诊断影响.

主要方法:

追溯分析了来自三个学术机构的9个SMARCA4-UT案例.
研究了临床病理学和分子特征.
在所有病例中都进行了GATA3免疫组织化学测试.

主要成果:

该队列包括9名患者 (5名男性,4名女性),平均年龄为54岁,中位数吸烟史为37包年.
在诊断时,中淋巴结参与 (56%) 和远程转移 (78%) 是常见的,平均存活时间为6个月.
所有瘤都显示BRG1表达的完全丧失. 值得注意的是,44% (4/9) 的SMARCA4-UTs对GATA3呈阳性,其中一个显示强烈和扩散的反应性.

结论:

在SMARCA4-UT中GATA3表达可能会带来诊断挑战.
将GATA3阳性SMARCA4-UT与其他GATA3阳性瘤区分开来,对于准确的预后和治疗计划至关重要.

关键词:

这就是BRG1的原因.在 GATA3 和 GATA3 之间.这就是SMARCA4的标志.在 SWI/SNF 中.免疫组织化学免疫组织化学没有分化的胸部瘤.

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