在REM睡眠行为障碍中具有莱维体的前进性痴呆症:一项多中心研究
Stephen Joza1, Michele T Hu2, Ki-Young Jung3
1Department of Neurology, Montreal Neurological Institute, Montreal, Canada.
概括
患有孤立的快速眼动睡眠行为障碍 (iRBD) 的人在痴呆症发生前几年就表现出注意力和执行功能障碍. 这种认知衰退强烈预测了勒维体痴呆症 (DLB) 和帕金森病 (PD).
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 孤立/异常性快速眼动睡眠行为障碍 (iRBD) 是一个显著的早期预测者痴呆症与莱维体 (DLB) 和帕金森病 (PD).
- 在iRBD患者中观察prodromal DLB进化为早期痴呆症预测因素提供了洞察力.
研究的目的:
- 确定认知变量是iRBD患者发展痴呆症的最强有力的预测因素.
- 分析认知衰退在DLB或PD转变之前的时间进展.
主要方法:
- 来自10个国际中心的754名iRBD参与者接受了年度神经心理评估.
- 竞争风险回归分析被用来确定最佳的痴呆症预测因素.
- 线性混合效应模型评估了神经心理测试表现的年度进展.
主要成果:
- 减少注意力和执行功能,特别是Trail Making Test Part B的表现,是早期DLB的最强的标识.
- 在iRBD参与者中,在phenoconversion之前的10年内观察到认知衰退.
- 在DLB和PD亚型之间区分口头记忆表现的变化.
结论:
- 在iRBD中,注意力和执行功能障碍是痴呆症发病的强有力的预测因素,在临床表现前几年开始下降.
- 情节性记忆的下降是区分痴呆症和帕金森症之间的关键,iRBD的第一个进展.
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