相关实验视频
Updated: Aug 11, 2026
09:18
Spheroid Assay to Measure TGF-β-induced Invasion
Published on: November 16, 2011
21.9K
机械压缩调节了瘤球状体入侵到3D原基质矩阵中的情况
Mrinal Pandey1, Young Joon Suh1, Minha Kim2
1Department of Biological and Environmental Engineering, 306 Riley-Robb Hall, Cornell University, Ithaca, NY 14853.
ArXiv
|July 18, 2023
概括
瘤压缩会增加恶性细胞的运动性和入侵性,而非瘤细胞的运动性会降低. 这突出了压缩压缩.
科学领域:
- 生物物理学的生物物理.
- 癌症生物学 癌症生物学
- 细胞力学 细胞力学
背景情况:
- 在狭窄的空间中瘤生长会产生压力应激.
- 压缩在瘤机制和入侵中的作用还没有得到充分研究,与张力不同.
- 了解瘤微环境力量对于癌症研究至关重要.
结论:
- 瘤压缩可以促进恶性细胞的入侵和运动.
- 压缩可能在健康和癌症上皮组织中发挥不同的作用.
- 瘤机制和入侵是理解癌症进展的关键因素.
相关概念视频
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:13Cell-matrix's Response to Mechanical Forces
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...