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Updated: Jul 23, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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在应对不断升级的间歇性压力时,Rap1小GTPase的异常调节会产生海马突触和认知功能障碍

Kathryn J Bjornson, Amanda M Vanderplow, Yezi Yang

    bioRxiv : the preprint server for biology
    |July 18, 2023
    PubMed
    概括

    重复的压力会通过影响海马体的树突脊柱稳定性来损害认知功能. 在CA3区域增加的突触Rap1驱动着这些压力诱导的变化在树突和认知.

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    Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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