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Updated: Jul 23, 2025

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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加快体质突变要求从异质瘤样本中获取全基因组和全外体序列数据

Shuangxi Ji1, Tong Zhu2, Ankit Sethia2

  • 1Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

bioRxiv : the preprint server for biology
|July 18, 2023
PubMed
概括

MuSE2.0通过使用并行处理加速了癌症基因组学中的体质突变检测. 这种新工具显著减少了计算时间,提高了癌症研究效率.

关键词:
计算速度的计算速度.多线程任务任务多线程任务单核酸变异的变化简化的突变调用.

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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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