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Updated: Jul 23, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

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母亲产前免疫激活与新生儿的大脑组织微观结构和代谢物度相关

Marisa N Spann^1,2, Ravi Bansal^3,4, Ezra Aydin¹

¹Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.

medRxiv : the preprint server for health sciences

|July 18, 2023

概括

产前暴露于母体免疫激活,由中白素-6和C反应蛋白表明,与新生儿大脑发育和运动功能的改变有关. 这些发现凸显了子女神经发育结果的潜在风险.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
免疫学免疫学免疫学

背景情况:

怀孕期间母亲的免疫激活是后代神经发育和精神疾病的潜在危险因素.
很少有人类研究研究了母亲免疫激活对新生儿大脑发育和运动功能的具体影响.

结论:

产前母亲免疫激活与新生儿脑组织特征和代谢物度的显著改变有关.
这些大脑变化与后代的运动发育轨迹有关.
这些发现强调了孕期母亲免疫状况对胎儿大脑发育和长期神经发育结果的重要性.

关键词:

扩散张力成像扩散张力成像早期的大脑发育的早期发展.磁共振光谱学磁共振光谱学孕产妇的免疫激活

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相关概念视频

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...