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使用美国乳腺癌患者队列的临床变量对BACH1的表达分析

N Maritza Dowling¹, Galina Khramtsova², Olufunmilayo Olopade²

¹The George Washington University.

Research square

|July 18, 2023

概括

在较大的乳腺瘤和黑人女性的瘤中,BACH1表达升高,这表明它可能是预后不佳的种族相关生物标志物. 这项研究研究了130个乳腺瘤组织中的BACH1蛋白水平.

科学领域:

在瘤学瘤学.
生物标志物发现发现
癌症转移癌症转移

背景情况:

研究表明,BACH1促进癌症转移,并调节代谢网络.
目前对乳腺瘤中BACH1蛋白表达及其作为生物标志物的临床相关性知之甚少.

研究的目的:

为了研究乳腺瘤中BACH1蛋白表达.
评估BACH1表达与临床变量之间的关联,包括瘤大小,乳腺癌亚型和患者种族.

主要方法:

在130个乳腺瘤组织的组织微阵列上利用免疫组织化学 (IHC).
评估了BACH1及其目标基因MCT1的表达.
使用曼-惠特尼U,克鲁斯卡尔-瓦利斯和顺序逻辑回归模型分析了与临床变量的关联.

主要成果:

在90%以上的瘤中检测到BACH1和MCT1.
与白人女性相比,在较大的瘤 (p=0.015) 和黑人女性的瘤中观察到显著更高的BACH1表达 (p=0.004).
BACH1表达在基底类瘤中最为丰富,特别是在黑人女性中; MCT1在所有种族的基底类瘤中都更高.

结论:

BACH1的表达与瘤大小和基本类型的亚型密切相关.
黑人女性瘤中的BACH1表达显著更高表明了潜在的种族相关生物标志物.
BACH1可能表明乳腺癌患者的预后不佳,特别是在特定种族群体内.

关键词:

在BACH1的基础上.黑人女性,黑人女性.在IHC中获得的得分.在MCT1中,MCT1是MCT1.基本类型类似的亚型乳腺癌乳腺癌乳腺癌

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