多个TonB同类对碳水化合物利用具有重要意义,通过细菌体的thetaiotaomicron
Rebecca M Pollet1,2,3, Matthew H Foley3, Supriya Suresh Kumar3
1Department of Chemistry, Vassar College, Poughkeepsie, NY, 12604, USA.
bioRxiv : the preprint server for biology
|July 18, 2023
概括
细菌菌体 (Bacteroides thetaiotaomicron) 使用TonB蛋白来运输多糖. B4对于粉分解至关重要,当B4缺少时,B6会补偿,这表明功能冗余.
科学领域:
- 微生物学 微生物学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 人的肠道微生物群,特别是 Bacteroides 种类,会降解复杂的多糖.
- 在 Bacteroides 中,多糖体的吸收是由TonB依赖转运体 (TBDTs) 介导的.
- 需要一个涉及TonB,ExbB和ExbD蛋白质的内膜复合体来进行TonB依赖的运输.
结论:
- B4在Bacteroides thetaiotaomicron中的多糖利用中发挥着重要作用.
- B4和B6之间的功能冗余增强了多糖的吸收能力.
- B蛋白的保护模式表明,在各个细菌类物种中存在不同程度的功能冗余.
更多相关视频
09:55From Constructs to Crystals – Towards Structure Determination of β-barrel Outer Membrane Proteins
Published on: July 4, 2016
13.5K
09:55Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles
Published on: August 12, 2021
3.9K
相关概念视频
Bacterial Phylum Bacteroidota
46
The phylum Bacteroidota includes over 700 species classified into four primary orders: Bacteroidales, Cytophagales, Flavobacteriales, and Sphingobacteriales. These gram-negative, non-sporulating rods exhibit saccharolytic capabilities and can be aerobic or fermentative, encompassing obligate aerobes, facultative aerobes, and obligate anaerobes. Many species display gliding motility, though some are nonmotile or use flagella. The genus Bacteroides is well-studied due to its significant role in...
46
Bacterial Phylum Tenericutes
43
The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
43
Bacterial Phylum Actinobacteria
37
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
37
Microbial Nutrition
105
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
105
Applications of Molecular Taxonomy
42
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
42
Bacterial Phylum Proteobacteria
44
Proteobacteria, one of the largest and most diverse bacterial phyla, encompasses a wide range of Gram-negative bacteria distinguished by their outer membrane composed of lipopolysaccharides. These microorganisms exhibit various metabolic capabilities, including phototrophy, chemolithotrophy, and heterotrophy, and thrive in diverse environments from soil to aquatic systems and host-associated niches. The phylum is divided into six classes: Alphaproteobacteria, Betaproteobacteria,...
44
