质母细胞瘤介质细胞过渡和入侵依赖于NF-κB/BRD2染色体复合体
Raghavendra Vadla1, Shunichiro Miki1, Brett Taylor1
1Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
bioRxiv : the preprint server for biology
|July 18, 2023
概括
质母细胞瘤中PTEN的丧失激活了NF-κB通路,通过BRD2.2促进了介酶过渡. 用BET-BD2抑制剂抑制PTEN-NF-κB-BRD2复合体可能提供一种新的质母细胞瘤治疗方法.
科学领域:
- 神经瘤学神经瘤学
- 分子生物学分子生物学
- 癌症遗传学 癌症遗传学
背景情况:
- 质母细胞瘤 (GBM) 是一种具有介质细胞 (MES) 亚型的侵袭性脑癌,与不良结果和治疗耐药性有关.
- PTEN基因和NF-κB通路与GBM恶性进展有关,但它们在MES过渡中的相互作用仍然不清楚.
结论:
- 发现了一种新的PTEN-NF-κB-BRD2信号轴驱动GBM介质细胞过渡.
- 用BET-BD2抑制剂向这种途径,为质母细胞瘤提供了一个有前途的治疗策略.
更多相关视频
09:36Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
Published on: August 29, 2018
10.3K
10:58Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
Published on: February 22, 2015
13.0K
相关概念视频
02:26NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
01:16TGF - β Signaling Pathway
7.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.4K