一个神经机制来区分社会威胁与社会安全
bioRxiv : the preprint server for biology
|July 18, 2023
概括
海马CA2区域在社会恐惧调节后区分威胁与非威胁的个体. 这个大脑区域将社会威胁信息整合到社会身份记忆中.
科学领域:
- 神经科学是一个神经科学.
- 社会行为 社交行为
- 记忆研究 记忆研究
背景情况:
- 适应性社会行为依赖于根据过去的经验来区分威胁与非威胁的个体.
- 对正面和负面社会相互作用的神经回路的理解越来越多,但在厌恶经历后歧视个体的机制仍然不清楚.
研究的目的:
- 根据过去的厌恶经验,研究基于同类的歧视背后的神经机制.
- 确定海马CA2金字塔神经元在社会威胁记忆和歧视中的作用.
主要方法:
- 在动物中开发了一种经过修改的社会恐惧调节范式.
- 利用化学遗传学和光遗传学来沉默海马的CA2金字塔神经元.
- 采用单光子成像来监测CA2中的神经活动.
主要成果:
- 社会恐惧调节诱导了与冲击相关的同类 (CS+) 和中性同类 (CS-) 之间的强有力的行为歧视.
- 沉默海马CA2神经元导致了普遍的回避,损害了CS+和CS-之间的歧视.
- 在CA2神经表示准确地区分了CS+和CS-动物的条件化后,并与行为歧视相关联.
- CA2表示编码了社会价值的抽象表示,独立于同类型的身份和位置.
结论:
- 海马的CA2神经元对于基于过去的厌恶经验来区分社会威胁至关重要.
- CA2次区域将社会价值纳入社会身份表征中,调解熟悉和基于威胁的社会记忆.
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