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Updated: Jul 23, 2025

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

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皮质杏仁体电路在塑造社会接触方面发挥着至关重要的作用

Russo Scott¹, Antonio Aubry¹, Romain Durand-de Cuttoli

¹Icahn School of Medicine at Mount Sinai.

Research square

|July 18, 2023

概括

雄性小鼠的后侧皮质杏仁体 (COApl),特别是雌激素受体1 (ESR1) 表达细胞,通过响应社会线索来驱动侵略性. 抑制这些细胞减少了侵略性行为,促进了社会调查.

科学领域:

神经科学是一个神经科学.
行为生物学行为生物学
伦理学伦理学伦理学

背景情况:

侵略是一种重要的进化保存行为,对社会层次结构和资源竞争至关重要.
小鼠的侵略行为包括食欲 (接近,调查) 和消费 (咬,) 阶段.

结论:

COApl ESR1 细胞通过响应社会刺激并增强其突出性来促进男性攻击性至关重要.
从COApl ESR1细胞投射到腹侧腹中下丘脑和中枢桃体,对于攻击性行为至关重要.

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