脊柱促进下降的电机输入
Giuliano Taccola1,2, Roger Kissane2,3, Stanislav Culaclii4
1Neuroscience Department, International School for Advanced Studies (SISSA), Bonomea 265, Trieste, Italy.
bioRxiv : the preprint server for biology
|July 18, 2023
概括
动态刺激 (DS) 通过增加脊髓内部神经元刺激性来增强脊髓损伤后的运动反应. 这种电神经调节能提高对剩余的脊柱上控制的反应能力,有助于运动输出恢复.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 发动机控制器的控制器
背景情况:
- 脊髓损伤通常会通过破坏脊髓上控制来损害运动功能.
- 目前正在探索电刺激技术,以恢复电机输出.
研究的目的:
- 为了研究动态刺激 (DS) 如何影响皮质脊髓输入和脊髓活动.
- 探索DS在脊髓损伤后促进运动反应方面的潜力.
主要方法:
- 开发了一个皮质脊髓平台,用于在多站点脊潜力 (CDP) 获取和DS过程中进行选择性皮质刺激.
- 通过记录CDP及其输入-输出配置文件,验证了外围注射器接口.
- 通过一个18电极外周道阵列给药DS.
主要成果:
- DS暂时促进了皮质脊髓运动反应.
- DS选择性地增加了脊髓内部神经元的兴奋性,在不改变下降运动命令的情况下处理皮质脊髓输入.
- DS增加了后突触脊髓内部神经元的兴奋性,以及它们对脊上控制的响应性.
结论:
- 通过调节脊髓内部神经元刺激性,DS可以增强运动输出.
- DS提高了对剩余的脊柱上输入的响应能力,支持其在运动功能恢复中的使用.
- 在由于神经功能障碍导致的运动输出受损的情况下,DS提供了一种有前途的电神经调节方法.
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