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Updated: Jul 23, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

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媒介激酶抑制抑制了唐氏综合征中过度活跃的干扰素信号传递

Kira Cozzolino1, Lynn Sanford2,3, Samuel Hunter2,3

  • 1Dept. of Biochemistry, University of Colorado, Boulder, CO, 80303, USA.

bioRxiv : the preprint server for biology
|July 18, 2023
PubMed
概括

唐氏综合征 (DS) 涉及过度活跃的干扰素 (IFN) 信号传输. 用皮质素A (CA) 抑制CDK8/CDK19激酶抑制了这种信号,影响了基因表达,新陈代谢和炎症,为DS提供了潜在的治疗策略.

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