在指甲上评估的微量元素的季节性模式.
Kaitlyn M Wojcik1, Ann Von Holle1, Katie M O'Brien1
1National Institute of Environmental Health Sciences.
Research square
|July 18, 2023
概括
脚指甲中的微量元素含量显示季节性模式,在8月中旬达到顶峰. 适应这种季节性对于对长期暴露和健康结果进行准确的流行病学研究至关重要.
科学领域:
- 环境流行病学环境流行病学
- 生物标记分析 生物标记分析
- 微量元素毒理学 微量元素毒理学
背景情况:
- 流行病学研究中的测量错误可能来自暴露生物标志物的季节性变化.
- 用脚指甲测量的微量元素的季节性尚未得到充分理解.
- 根据季节性模式进行调整可能会提高准确性,并减少暴露与健康结果关联的偏差.
研究的目的:
- 评估各种微量元素的脚指甲测量中的季节性模式.
- 为了确定脚指甲微量元素水平是否表现出可预测的年度波动.
主要方法:
- 姐妹研究的参与者在报名时提供了脚指甲剪切.
- 在已清洗的指甲样本中测量了17种微量元素.
- 三角函数回归模型分析季节性基于脚指甲采集日期.
主要成果:
- 在17种微量元素中的11种元素中观察到显著的季节性模式,包括铁,,,,,,,,,,,,,,,,,锡和.
- 大多数元素的季节性峰值发生在8月中旬左右.
- 在两个独立的女性样本和实验室分析中,季节性模式是一致的.
结论:
- 脚指甲的微量元素水平显示出显著的季节性,特别是铁,和等元素.
- 考虑到这些季节性变化对于准确的流行病学研究,将微量元素暴露与健康联系起来至关重要.
- 观察到的脚指甲痕迹元素夏季峰值的潜在生物学或环境原因需要进一步调查.
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