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Updated: Jul 23, 2025

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

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一个IGHV1-69广泛中和的流感HA干抗体的严格和复杂的序列约束

Qi Wen Teo1,2, Yiquan Wang1, Huibin Lv1,2

  • 1Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.

bioRxiv : the preprint server for biology
|July 18, 2023
PubMed
概括

轻链序列对于广泛中和性流感抗体CR9114的关键,它向血凝素 (HA) 干. 这一发现促进了对抗体特异性的理解,用于开发通用流感疫苗.

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Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
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