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SIRT1通过GSDME - IL18轴调节肝细胞编程细胞死亡在人类和老鼠肝移植中

Kentaro Kadono1, Hidenobu Kojima1, Siyuan Yao1

  • 1David Geffen School of Medicine, University of California-Los Angeles.

Research square
|July 18, 2023
PubMed
概括

肝细胞Sirtuin 1 (SIRT1) 通过抑制细胞亡和GSDME介导的细胞死亡来保护在移植期间免受感冒引起的肝损伤. 准SIRT1-IL18通路可能会改善肝移植的存活率.

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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