酒精通过向核accumbens输入的血清素来抑制社交性
Catherine Marcinkiewcz1, Ruixiang Wang1, Kanza Khan2
1University of Iowa.
Research square
|July 18, 2023
概括
长期使用酒精会通过过度激活血清素神经元,从而抑制大脑中多巴胺释放,导致社会回避. 这表明,对于用于治疗酒精使用障碍的血清激素增强药物,应谨慎使用.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 成研究 研究成研究
背景情况:
- 社会互动对于激励和恢复至关重要,但它在神经精神疾病中受损,例如酒精使用障碍 (AUD).
- 在AUD中减少社交行为可能会阻碍恢复并增加复发风险.
- 慢性间歇性乙醇 (CIE) 暴露会诱导社会回避,这与背脊拉菲核 (DRN) 血清素 (5-HT) 神经元的过度活动有关.
结论:
- 在长期暴露于酒精后,过度的血清激素信号会促进社会厌恶.
- 这种厌恶是通过抑制核内中多巴胺释放的介导.
- 提高血激素的药物可能对AUD患者有害.
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