采用T细胞疗法介导的固体瘤消除所需的内免疫三位体是采用T细胞疗法介导的固体瘤的消除
Gabriel Espinosa-Carrasco1, Aurora Scrivo2, Paul Zumbo3,4
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
bioRxiv : the preprint server for biology
|July 18, 2023
概括
特定于瘤的CD4 T细胞对于有效的癌症免疫疗法至关重要. 它们与CD8 T细胞和抗原呈现细胞形成三细胞群,增强CD8 T细胞功能并消除瘤.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 细胞疗法细胞疗法
背景情况:
- 癌症患者的瘤反应性CD8 T细胞往往功能不良,限制了采用T细胞转移 (ACT) 癌症免疫治疗的有效性.
- 虽然ACT显示出有希望的结果,但转移的CD8 T细胞经常失去效应器功能,特别是在固体瘤中.
结论:
- 内三位体对抗瘤免疫力至关重要,揭示了CD4 T细胞在增强CD8 T细胞细胞毒性和癌症根除方面发挥的新角色.
- 在人类肺部瘤中,这些三元体的存在与免疫检查点阻塞的临床反应相关,突出显示了它们在ACT之外的重要性.
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