与COVID-19相关的犀牛轨道大脑粘菌病与血管侵袭:致命的后果
Nur Syazwani Redzuwan1,2, Andrea Lillianne Barr Kumarakulasinghe2, Wan Mariny W Md Kasim3
1Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.
Cureus
|July 18, 2023
概括
这项案例研究突出了在服用类固醇的糖尿病COVID-19患者中出现的严重侵入性粘性肌病并发症,包括轨道顶部综合征和视网膜中枢动脉封闭. 密切监测高风险患者对于预防这种侵袭性真菌感染至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 治疗COVID-19,特别是高剂量类固醇治疗,可以增加机会性感染的风险.
- 侵入性粘真菌菌是一种罕见但有攻击性的真菌感染,通常影响免疫力低下的人.
- 失控的糖尿病是一种显著的风险因素,用于粘膜菌病.
研究的目的:
- 报告一种罕见的侵袭性粘膜瘤病例,呈现为轨道顶部综合征和视网膜中枢动脉封闭.
- 为了强调在COVID-19患者中管理这种侵袭性真菌感染的挑战.
- 强调合理使用免疫调节剂和对高风险患者的警监测的重要性.
主要方法:
- 一个中年男性患有并发病的病例报告.
- 用高累积类固醇治疗治疗COVID-19肺炎的治疗方法.
- 用全身抗真菌药物和局部安二乙注射治疗侵入性粘性菌.
主要成果:
- 右轨道顶部综合征的发展和视网膜中枢动脉封闭COVID-19后治疗.
- 尽管采取了积极的医疗和抗真菌干预措施,但粘真菌菌的快速进展.
- 患者与这种危及生命的真菌感染作斗争.
结论:
- 侵袭性粘性菌可以在免疫力低下的患者中造成毁灭性的并发症,包括那些接受COVID-19治疗的人.
- 在COVID-19管理中,合理使用免疫调节剂和类固醇是必不可少的.
- 对机会性感染的密切监测至关重要,特别是在糖尿病和其他并发症的患者中.
相关概念视频
Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...


