在COVID-19前的时代,针对SARS-CoV-2的HLA变体和TCR多样性
Stéphane Buhler1, Zuleika Calderin Sollet1, Florence Bettens1
1Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland.
HLA
|July 18, 2023
概括
健康的个体拥有强大的T细胞库,能够识别SARS-CoV-2,这表明他们对病毒有天生的免疫准备. 这种准备,可能是由于异质免疫,可以解释未暴露人群的有效反应.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- T细胞反应和HLA抗原呈现对于控制COVID-19等病毒感染至关重要.
- 的呈现深度和T细胞谱的宽度都会影响疾病的结果.
- 异质免疫可以在以前未接触过的个体中引起T细胞对SARS-CoV-2的反应.
研究的目的:
- 在健康的捐赠者和移植后接受者中调查抗SARS-CoV-2T细胞谱.
- 分析T细胞受体 (TCR) CDR3β序列,并预测HLA类I对SARS-CoV-2的结合.
主要方法:
- 来自免疫测序数据的143310个公开可用的SARS-CoV-2特异性T细胞序列的分析.
- 在116名健康捐赠者和116名移植接受者的队列中对350万个克隆类型的调查 (COVID-19前的时代).
- 使用SARS-CoV-2参考蛋白质组和高分辨率基因定型的HLA类I结合预测.
主要成果:
- 个体表现出识别SARS-CoV-2的遗传准备,匹配T细胞克隆型的中位积累频率为5%.
- 队列中的所有HLA类I变异组合都显示出具有广泛的能力,可以呈现数百种SARS-CoV-2.
- 这些发现表明先前存在的T细胞记忆或交叉反应有助于免疫反应.
结论:
- 人类的遗传构成非常适合识别SARS-CoV-2.
- 广泛的HLA类I呈现能力表明T细胞介导免疫力对病毒的强大潜力.
- 异种免疫和TCR重组可能解释了观察到的T细胞谱,可能会在接种疫苗之前对非免疫性受损个体有效的SARS-CoV-2反应负责.
关键词:
哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈这就是SARS-CoV-2病毒.在TCR中,可以使用TCR.多样性的多样性多样性的多样性不同类免疫力 不同类免疫力免疫复合 免疫复合 免疫复合更多相关视频
06:08Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
Published on: September 8, 2023
1.3K
08:41Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.8K
相关概念视频
01:05Single Nucleotide Polymorphisms-SNPs
15.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.3K
01:28Diversity of Antigen Receptors
647
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
647
00:36Viral Mutations
32.5K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.5K