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肝脏和肠道的分泌都需要调节大脑在高暴露期间的

Steven Hutchens¹, Thomas P Jursa², Ashvini Melkote¹

¹Division of Pharmacology and Toxicology, College of Pharmacy, and Institute for Neuroscience, The University of Texas at Austin, Austin, Texas, United States.

American journal of physiology. Gastrointestinal and liver physiology

|July 18, 2023

概括

肝脏和肠道的分泌对于在高暴露期间控制大脑水平至关重要. 肠道和肝脏也一起工作,清除早期生命暴露中积累的.

科学领域:

神经科学是一个神经科学.
毒理学毒理学毒理学
生理学生理学生理学

背景情况:

(Mn) 是必需的,但在高水平上是神经毒性.
肝脏和肠道分泌调节Mn水平,肝脏在生理条件下是主要的.
令人惊的是,肠道在控制大脑Mn的过程中补偿了肝脏Mn分泌损失.

研究的目的:

研究肝脏和肠道分泌在高暴露期间对大脑的调节中的作用.
为了确定这些作用是否在生理和高暴露条件之间有所不同.
了解Mn清除机制及其对神经毒性的影响.

主要方法:

使用组织特异性淘汰小鼠 (肝或肠特异性Slc30a10淘汰小鼠) 抑制Mn分泌.
在生命早期和晚年阶段给予高暴露.
评估大脑的Mn水平并进行神经运动测试.

主要成果:

肝脏和肠道的Mn分泌都对控制大脑Mn在高暴露期间至关重要,与生理条件不同.
早期的Mn暴露,即使是排泄受损,也导致晚年大脑Mn水平正常化.
神经运动测试表明,肝脏和肠道的Mn分泌会调节Mn的神经毒性.

结论:

肝脏和肠道的Mn分泌在早期暴露后清除累积的Mn中起到补偿作用.
这些分泌途径对于管理大脑Mn稳态和在高Mn暴露期间减轻神经毒性至关重要.
这些发现挑战了先前的假设,并强调了肝脏和肠道分泌在相关暴露场景中的同等重要性.

关键词:

在SLC30A1010中使用.在 SLC39A1414 中.在ZIP14中,您可以使用ZIP14.ZnT10 ZnT10 是一个酸是一种酸.

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